Florida vs. Mississippi State Final Odds and Predictions: Billy Napier's Last Stand

Florida is favored against Mississippi State on Homecoming
Oct 11, 2025; College Station, Texas, USA; Florida Gators head coach Billy Napier looks on during the third quarter against the Texas A&M Aggies at Kyle Field. Mandatory Credit: Maria Lysaker-Imagn Images
Oct 11, 2025; College Station, Texas, USA; Florida Gators head coach Billy Napier looks on during the third quarter against the Texas A&M Aggies at Kyle Field. Mandatory Credit: Maria Lysaker-Imagn Images | Maria Lysaker-Imagn Images

Amidst all the chaos, amidst all the rumors, and amidst the backdrop of Homecoming, the Florida Gators are going to take the field today against a game Mississippi State squad. The Bulldogs are 4-2 on the season, while Florida is 2-4.

Billy Napier is hoping this isn't his final game in The Swamp, but a loss today would more than likely seal his fate for good.

Florida vs Mississippi State Final Odds

Spread

Over/Under

Moneyline

Florida -9.5

50.5 Points

Florida -400
Miss State +300

Deep in Gator lore is a loss to Mississippi State that facilitated a coaching change in Gainesville, so the parallels for today are certainly possible. After a disastrous 2024 campaign, the Bulldogs knocked off Arizona State and took Tennessee to overtime.

But even with the circus that seems to be surrounding Florida, the Gators still have a more than manageable pathway to win this game. The issue for Mississippi State is that they struggle to get pressure on the QB, and their passing game isn't explosive. Mississippi State is in the bottom 25 in the country for sacks allowed, tackles for a loss of defense, and passes over 10 yards.

If DJ Lagway has time in the pocket to get comfortable and doesn't have someone in his face every single snap, there are reasons to believe the sheer talent of Florida's playmakers should be enough to get over the finish line.

The Bulldogs are top 25 in explosive running plays, and Florida's question marks at defensive tackle should create some unease on defense, but Florida's linebackers should also be able to do just enough to slow Mississippi State down and get stops.

A loss today would seal Billy Napier's fate. A win might not matter either, but at least for one afternoon in The Swamp, this should be a game even Napier can't screw up.

Key word, should be.

Predictions

Hail Florida Hail Member

Final Prediction

Benjamin

Florida 31 Miss State 17

Godwin

Florida 45 Miss State 17

Corey

Florida 34 Miss State 23

Alexis

Florida 31 Miss State 21

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